Director/Senior Director, Enterprise IT Systems & Cybersecurity

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.

Position Overview

We are seeking a hands-on Senior Director of Enterprise IT Systems to lead our systems infrastructure and cloud initiatives within a dynamic biotech environment. This role will be responsible for architecting, implementing, and managing company-wide IT solutions with a strong emphasis on cybersecurity, compliance, and scalability.

You will report directly to the Head of IT and collaborate closely with other business teams to ensure our cloud and on-premise computer systems support scientific innovation and operational excellence.

Responsibilities

• Implement the strategic vision for IT systems across the enterprise, aligning with long-term business and scientific goals.
• Drive enterprise-wide system transformation, migration, and modernization initiatives, ensuring scalability, security, and innovation.
• Ensure alignment with cybersecurity frameworks (NIST CSF v2), privacy regulations, Sarbanes-Oxley, and risk management strategies for all supported platforms.
• Ensure compliance with regulations specific to the life sciences industry (HIPAA, GxP, FDA 21CFR11).
• Support cross-functional collaboration with executive leadership, R&D, Clinical, TechOps, G&A, and other business units to support major initiatives.
• Lead and mentor a team of Immunome and MSP-based engineers and system administrators, fostering a high-performance culture and continuous improvement.
• Help develop and manage multi-year infrastructure budgets, third-party relationships, contracts, and licenses.
• Maintain the availability, confidentiality, and integrity of data managed by Immunome IT systems and service providers. Monitor and respond to security threats and incidents.
• Architect and manage mobile device and application management strategies using Microsoft Intune and Jamf.
• Leverage ServiceNow for ITSM, ITAM, automation, and operational efficiency.
• Develop and enforce governance policies and procedures for system usage and data protection.
• Report on system performance, risks, and strategic opportunities.

Qualifications

• Bachelor’s or Master’s degree in Computer Science, Information Systems, or related field.
• 12+ years of progressive IT experience is required. A minimum of 6+ years in systems leadership at the enterprise level is preferred.
• Demonstrated work experience in the pharmaceutical/life sciences industry is required.

Knowledge and Skills

• Proven track record of leading transformation initiatives in complex, regulated environments.
• Expertise in Microsoft Azure, Entra, M365, Intune, Defender, Purview, and SharePoint, with oversight of Jamf and ServiceNow implementations.
• Demonstrated success in cybersecurity leadership, compliance management, and business stakeholder engagement.
• Exceptional leadership, communication, project management, and planning skills.
• Advanced certifications such as PMP, CISM, Azure Solutions Architect Expert, and Microsoft Certified Cybersecurity Architect are preferred.

Washington State Pay Range$216,597—$281,306 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.