Vice President, Information Technology and Cyber Security

Company Description

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Mass.

Culture is key and all Bicycle employees actively embrace and role model our company values:  

• We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can't change the world if you don't have determination
• We are One Team. We only succeed when we work together. 

Job Description

The Vice President, Information Technology and Cyber Security is responsible for developing and running the information technology architecture, strategy and governance to ensure Bicycle develops the right capabilities and infrastructure to grow into a world class end to end pharmaceutical company. 

You will be responsible for building and developing a forward thinking team that are embedded within the organization and seen as critical contributors to Bicycle’s ambitious plans and future successes.

Key responsibilities

• Develop an integrated enterprise-wide IT strategy that prepares the organization for commercial launch, future growth and scale. Covering the full life cycle of the business from research and innovation, through to clinical development, CMC, supply chain and logistics, commercial and corporate.
• Develop tailored IT and data solutions for each business area prioritizing wherever possible integration within an overall enterprise-wide architecture roadmap.
• Develop and lead the information technology and cyber security team to deliver current and future capabilities and activities across the organisation – providing deep and broad business, functional and domain knowledge to enhance IT’s effectiveness of aligning business outcomes with technology solutions.
• Working with key stakeholders across the exec and LT, provide demand triage, design and delivery services for appropriate and effective operational and change management solutions to fulfil business requirements. Ensure plans are well communicated and have key stakeholder approval.
• Partner with the functional leaders in prioritizing business-specific demand as part of portfolio planning process.
  • Partner with the research and innovation, clinical development, CMC and supply chain, finance, corporate and commercial functions to provide input and assist in the development of an accelerated roadmap strategy for commercial launch.
• Ensure the operational reliability and performance of all developed solutions prior to transitioning into production.
• Enhance and rationalize IT infrastructure, applications and systems required to protect and grow the full Bicycle end to end portfolio, utilizing ML and AI where appropriate.
• Oversee IT portfolio budget planning, prioritization and maximizing the resources to deliver business plans. Work closely with finance to develop a group technology budget that is clearly understood maximizing ROI on OPEX and CAPEX spend.
  • Manage the IT procurement process in close partnership with finance and the  function/process owner, ensuring effective business process and requirements analysis is conducted. 
• Protect the continuity, integrity, and availability of the Bicycle IT systems and maintain compliance with information security management system (ISMS) ISO27001. Manage ISMS ISO27001 audits on a periodic basis. Ensure cyber security sits at the core of Bicycle ways of working and is understood and supported by the audit committee and the board of directors. Ensure adequate processes continue to function to identify and escalate cybersecurity incidents as appropriate and evaluate disclosure requirements under SEC rules.
• Support and enable a data governance, control, and platform implementation strategy that ensures Bicycle proprietary information is held, shared effectively, and secured across the company and relevant 3rd parties, adhering to regulatory requirements (21 CFR part 11 and GxP).
• Maintain effective IT application controls and change management controls and meeting SOX compliance requirements and support associated annual audits.
• Business Engagement – together with Strategy, HR and Finance, provide insights, thought leadership and guidance on changing industry landscape ensuring Bicycle optimizes budget priorities around future resource requirements.

Qualifications

• You will be a dynamic enterprise leader, with experience of creating a compelling vision for technology solutions that support the delivery of corporate strategies and commercial goals.
• Accomplished track record of enterprise IT delivery within a fully commercialized Biotech, with strong program governance and change management, exposure to multiple technology domains, enterprise architecture and roadmaps.
• Proven in leading and inspiring teams and wider stakeholders through ambiguity, able to overcome resistance and win hearts and minds.
• A leader in cyber security, optimizing strategic partnerships and managing enterprise risk.  
• Track record in identifying and adopting cutting-edge technology that will make a meaningful difference to the company, with the ability to influence organizations to adopt a more digital culture.
• An innovator with strong external networks that can create additional organizational value.
• Strong commercial awareness, experienced in building budgets that optimize spend, future proof the organization and can be tracked for ROI. Builds accountability and financial transparency.
• Life science data and cyber regulatory understanding and adherence.
• Ability to simplify complex issues, and to create a simple narrative to complex situations that enable better decision making, solution development and adoption.
• Self-aware, possessing high degrees of emotional intelligence, able to understand different points of view and respond accordingly

Additional Information

• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Flexible working environment
• Competitive reward including annual company bonus 
• Employee recognition schemes
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
• Employer contribution to pension (employee does not have to contribute) 
• Life assurance cover 4x basic salary 
• Private Medical Insurance, including optical and dental cover. 
• Group income protection
• Employee assistance program
• Health Cash Plan
• Access to company subsidized gym membership.
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. 
• Cycle to work scheme 

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.